Karyotypic Flexibility of the Complex Cancer Genome and the Role of Polyploidization in Maintenance of Structural Integrity of Cancer Chromosomes

Ongoing chromosomal instability in neoplasia (CIN) generates intratumor genomic heterogeneity and limits the efficiency of oncotherapeutics. Neoplastic human cells utilizing the alternative lengthening of telomeres (ALT)-pathway, display extensive structural and numerical CIN. To unravel patterns of...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Raftopoulou, Christina, Roumelioti, Fani-Marlen, Dragona, Eleni, Gimelli, Stefanie, Sloan-Béna, Frédérique, Gorgoulis, Vasilis, Antonarakis, Stylianos E., Gagos, Sarantis
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139464/
https://ncbi.nlm.nih.gov/pubmed/32150835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030591
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