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Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation

In Parkinson’s disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions. We previously demonstrated that injection of alpha-synuclein fibrils unilaterally into the olfactory bulb o...

詳細記述

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書誌詳細
出版年:Neurobiol Dis
主要な著者: Mezias, Christopher, Rey, Nolwen, Brundin, Patrik, Raj, Ashish
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138530/
https://ncbi.nlm.nih.gov/pubmed/31628991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104623
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