Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4(+) CAR T Cell Efficacy

Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived extracellular vesicles. Advanced neuroblastoma is an aggressive childhood tumor without curative treatment options for most relapsed patients...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Ali, Solin, Toews, Karin, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Grunewald, Laura, Oevermann, Lena, Deubzer, Hedwig E., Tüns, Alicia, Jensen, Michael C., Henssen, Anton G., Eggert, Angelika, Schulte, Johannes H., Schwich, Esther, Rebmann, Vera, Schramm, Alexander, Künkele, Annette
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137471/
https://ncbi.nlm.nih.gov/pubmed/32296437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00531
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