mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers

Epithelial ovarian cancer is characterized by universal TP53 mutations, which result in G1/S checkpoint deficiencies. Therefore, it is hypothesized that the abrogation of the G2/M checkpoint with Wee1 inhibitor might preferentially sensitize TP53-defective ovarian cancer cells. Given the extremely h...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Am J Cancer Res
Main Authors: Li, Fuxia, Guo, Ensong, Huang, Jia, Lu, Funian, Yang, Bin, Xiao, Rourou, Liu, Chen, Wu, Xue, Fu, Yu, Wang, Zizhuo, Peng, Shaohua, Lei, Yu, Guo, Zhongzhen, Li, Lei, Xi, Ling, Sun, Chaoyang, Liu, Si, Chen, Gang
פורמט: Artigo
שפה:Inglês
יצא לאור: e-Century Publishing Corporation 2020
נושאים:
Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136919/
https://ncbi.nlm.nih.gov/pubmed/32266099
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