mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers

Epithelial ovarian cancer is characterized by universal TP53 mutations, which result in G1/S checkpoint deficiencies. Therefore, it is hypothesized that the abrogation of the G2/M checkpoint with Wee1 inhibitor might preferentially sensitize TP53-defective ovarian cancer cells. Given the extremely h...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Am J Cancer Res
Asıl Yazarlar: Li, Fuxia, Guo, Ensong, Huang, Jia, Lu, Funian, Yang, Bin, Xiao, Rourou, Liu, Chen, Wu, Xue, Fu, Yu, Wang, Zizhuo, Peng, Shaohua, Lei, Yu, Guo, Zhongzhen, Li, Lei, Xi, Ling, Sun, Chaoyang, Liu, Si, Chen, Gang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: e-Century Publishing Corporation 2020
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136919/
https://ncbi.nlm.nih.gov/pubmed/32266099
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller