mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers

Epithelial ovarian cancer is characterized by universal TP53 mutations, which result in G1/S checkpoint deficiencies. Therefore, it is hypothesized that the abrogation of the G2/M checkpoint with Wee1 inhibitor might preferentially sensitize TP53-defective ovarian cancer cells. Given the extremely h...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Am J Cancer Res
Κύριοι συγγραφείς: Li, Fuxia, Guo, Ensong, Huang, Jia, Lu, Funian, Yang, Bin, Xiao, Rourou, Liu, Chen, Wu, Xue, Fu, Yu, Wang, Zizhuo, Peng, Shaohua, Lei, Yu, Guo, Zhongzhen, Li, Lei, Xi, Ling, Sun, Chaoyang, Liu, Si, Chen, Gang
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: e-Century Publishing Corporation 2020
Θέματα:
Original Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136919/
https://ncbi.nlm.nih.gov/pubmed/32266099
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