Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy

BACKGROUND: Untreated HIV infection leads to alterations in HIV-specific CD4(+) T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after suppression of viral replication with ant...

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Udgivet i:EBioMedicine
Main Authors: Niessl, Julia, Baxter, Amy E., Morou, Antigoni, Brunet-Ratnasingham, Elsa, Sannier, Gérémy, Gendron-Lepage, Gabrielle, Richard, Jonathan, Delgado, Gloria-Gabrielle, Brassard, Nathalie, Turcotte, Isabelle, Fromentin, Rémi, Bernard, Nicole F., Chomont, Nicolas, Routy, Jean-Pierre, Dubé, Mathieu, Finzi, Andrés, Kaufmann, Daniel E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136607/
https://ncbi.nlm.nih.gov/pubmed/32268275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102727
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