Altered differentiation is central to HIV-specific CD4(+) T cell dysfunction in progressive disease

Dysfunction of virus-specific CD4(+) T cells in chronic human infections is poorly understood. We performed genome-wide transcriptional analyses and functional assays of CD4(+) T cells specific for human immunodeficiency virus (HIV) from HIV-infected people prior and after initiation of antiretrovir...

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Bibliografiset tiedot
Julkaisussa:Nat Immunol
Päätekijät: Morou, Antigoni, Brunet-Ratnasingham, Elsa, Dubé, Mathieu, Charlebois, Roxanne, Mercier, Eloi, Darko, Sam, Brassard, Nathalie, Nganou-Makamdop, Krystelle, Arumugam, Sahaana, Gendron-Lepage, Gabrielle, Yang, Lifei, Niessl, Julia, Baxter, Amy E., Billingsley, James M., Rajakumar, Premeela A., Lefebvre, François, Johnson, R. Paul, Tremblay, Cécile, Routy, Jean-Pierre, Wyatt, Richard T., Finzi, Andrés, Douek, Daniel C., Kaufmann, Daniel E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642691/
https://ncbi.nlm.nih.gov/pubmed/31308541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0418-x
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