Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau

Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progressio...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Ma, Xiaojuan, Zhu, Yi, Lu, Jinxia, Xie, Jingfei, Li, Chong, Shin, Woo Shik, Qiang, Jiali, Liu, Jiaqi, Dou, Shuai, Xiao, Yi, Wang, Chuchu, Jia, Chunyu, Long, Houfang, Yang, Juntao, Fang, Yanshan, Jiang, Lin, Zhang, Yaoyang, Zhang, Shengnan, Zhai, Rong Grace, Liu, Cong, Li, Dan
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136026/
https://ncbi.nlm.nih.gov/pubmed/32250733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51859
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