Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). In the SASP of cells that became senescent following several in vitro chemical and physical stress, we identified the IGFBP-4 protein that can be considered a general stress mediator. This...

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Vydáno v:eLife
Hlavní autoři: Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Galano, Giovanni, De Rosa, Roberto, Melone, Mariarosa AB, Peluso, Gianfranco, Galderisi, Umberto
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136022/
https://ncbi.nlm.nih.gov/pubmed/32223893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54523
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