TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the tr...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Sacramento, Laís Amorim, Benevides, Luciana, Maruyama, Sandra Regina, Tavares, Lucas, Fukutani, Kiyoshi Ferreira, Francozo, Marcela, Sparwasser, Tim, Cunha, Fernando Queiroz, Almeida, Roque Pacheco, da Silva, João Santana, Carregaro, Vanessa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135367/
https://ncbi.nlm.nih.gov/pubmed/32210480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008435
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