Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells

BACKGROUND: Irinotecan (IRI) is considered an option for second-line treatment of advanced gastric cancer; however, acquired drug resistance currently limits its clinical application. Recently, many researchers have shown that autophagy plays a crucial role in the resistance of tumor cells to chemot...

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Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Zhu, Qingyun, Guo, Yuehui, Chen, Shiwei, Fu, Daiquan, Li, Yanxiang, Li, Zhi, Ni, Caifang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135144/
https://ncbi.nlm.nih.gov/pubmed/32308415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S240803
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