Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy

AIM: We aim to demonstrate that a local nanoparticle-mediated hyperthermia can effectively eliminate tumor-associated Tregs and thereby boost checkpoint blockade-based immunotherapy. MATERIALS & METHODS: Photothermal therapy (PTT), mediated with systemically administered stealthy iron-oxide nano...

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Vydáno v:Nanomedicine (Lond)
Hlavní autoři: Chen, Hongwei, Luan, Xin, Paholak, Hayley J, Burnett, Joseph P, Stevers, Nicholas O, Sansanaphongpricha, Kanokwan, He, Miao, Chang, Alfred E, Li, Qiao, Sun, Duxin
Médium: Artigo
Jazyk:Inglês
Vydáno: Future Medicine Ltd 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132783/
https://ncbi.nlm.nih.gov/pubmed/31868112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2019-0190
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