Loss of non‐canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons

KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron‐specific protein initially identified as the chloride (Cl(−)) extruder critical for hyperpolarizing GABA(A) receptor currents. Independently of its canonical function as a K‐Cl cotransporter, KCC2 regulates the actin cytoskelet...

Full description

Saved in:
Bibliographic Details
Published in:EMBO Rep
Main Authors: Mavrovic, Martina, Uvarov, Pavel, Delpire, Eric, Vutskits, Laszlo, Kaila, Kai, Puskarjov, Martin
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132201/
https://ncbi.nlm.nih.gov/pubmed/32064760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948880
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items