An Antiviral Mechanism of Nitric Oxide: Inhibition of a Viral Protease

Although nitric oxide (NO) kills or inhibits the replication of a variety of intracellular pathogens, the antimicrobial mechanisms of NO are unknown. Here, we identify a viral protease as a target of NO. The life cycle of many viruses depends upon viral proteases that cleave viral polyproteins into...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Saura, Marta, Zaragoza, Carlos, McMillan, Audrey, Quick, Richard A, Hohenadl, Christine, Lowenstein, John M, Lowenstein, Charles J
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press. 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7129050/
https://ncbi.nlm.nih.gov/pubmed/10023767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1074-7613(00)80003-5
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