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Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization
[Image: see text] We describe our design, synthesis, and chemical study of a set of functional epidithiodiketopiperazines (ETPs) and evaluation of their activity against five human cancer cell lines. Our structure–activity relationship-guided substitution of ETP alkaloids offers versatile derivatiza...
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| Publicado no: | J Org Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2020
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7127967/ https://ncbi.nlm.nih.gov/pubmed/32126173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b03371 |
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