Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Lee, Chaewoon, Lee, Jin Moo, Lee, Na-Ra, Kim, Dong-Eun, Jeong, Yong-Joo, Chong, Youhoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Ltd. 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127646/
https://ncbi.nlm.nih.gov/pubmed/19625187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.07.009
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