Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues

A series of the novel C-5 alkynyl pyrimidine nucleoside analogues (1–14) in which the sugar moiety was replaced by the conformationally restricted Z- and E-2-butenyl spacer between the phthalimido and pyrimidine ring were synthesized by using Sonogashira cross-coupling reaction. Cytostatic activity...

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Publicado no:Bioorg Med Chem
Main Authors: Gazivoda, Tatjana, Raić-Malić, Silvana, Krištafor, Vedran, Makuc, Damjan, Plavec, Janez, Bratulić, Siniša, Kraljević-Pavelić, Sandra, Pavelić, Krešimir, Naesens, Lieve, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Mintas, Mladen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127491/
https://ncbi.nlm.nih.gov/pubmed/18424155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.074
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