Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor

The coronavirus main protease, M(pro), is considered a major target for drugs suitable to combat coronavirus infections including the severe acute respiratory syndrome (SARS). In this study, comprehensive HPLC- and FRET-substrate-based screenings of various electrophilic compounds were performed to...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Martina, Erika, Stiefl, Nikolaus, Degel, Björn, Schulz, Franziska, Breuning, Alexander, Schiller, Markus, Vicik, Radim, Baumann, Knut, Ziebuhr, John, Schirmeister, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127417/
https://ncbi.nlm.nih.gov/pubmed/16216498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.09.012
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