Characterization of trans‐ and cis‐cleavage activity of the SARS coronavirus 3CL(pro) protease: basis for the in vitro screening of anti‐SARS drugs

Severe acute respiratory syndrome (SARS) has been globally reported. A novel coronavirus (CoV), SARS‐CoV, was identified as the etiological agent of the disease. SARS‐CoV 3C‐like protease (3CL(pro)) mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, pl...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Principais autores: Lin, Cheng-Wen, Tsai, Chang-Hai, Tsai, Fuu-Jen, Chen, Pei-Jer, Lai, Chien-Chen, Wan, Lei, Chiu, Hua-Hao, Lin, Kuan-Hsun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2004
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127318/
https://ncbi.nlm.nih.gov/pubmed/15358553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2004.08.017
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