SARS-CoV 3CL(pro) inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

Quinone-methide triterpenes, celastrol (1), pristimerin (2), tingenone (3), and iguesterin (4) were isolated from Triterygium regelii and dihydrocelastrol (5) was synthesized by hydrogenation under palladium catalyst. Isolated quinone-methide triterpenes (1–4) and 5 were evaluated for SARS-CoV 3CL(p...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Ryu, Young Bae, Park, Su-Jin, Kim, Young Min, Lee, Ju-Yeon, Seo, Woo Duck, Chang, Jong Sun, Park, Ki Hun, Rho, Mun-Chual, Lee, Woo Song
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Ltd. 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127101/
https://ncbi.nlm.nih.gov/pubmed/20167482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.152
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