The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection

The intrasplenic injection of human peripheral blood mononuclear cells (PBMCs) into severely immune deficient NOD/SCID mice, causes a massive and transient dominant expansion of human B cells in the spleen. This permits the easy isolation of human monoclonal antibodies specific for different antigen...

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Detalhes bibliográficos
Publicado no:J Immunol Methods
Main Authors: Steyaert, Sophia, Verhoye, Lieven, Beirnaert, Els, Donners, Helen, Fransen, Katrien, Heyndrickx, Leo, Vanham, Guido, Leroux-Roels, Geert, Vanlandschoot, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125539/
https://ncbi.nlm.nih.gov/pubmed/17258763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2006.12.003
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