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Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
Human enterovirus (EV) belongs to the picornavirus family, which consists of over 200 medically relevant viruses. A peptidomimetic inhibitor AG7088 was developed to inhibit the 3C protease of rhinovirus (a member of the family), a chymotrypsin-like protease required for viral replication, by forming...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Ltd.
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125518/ https://ncbi.nlm.nih.gov/pubmed/18583140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.06.015 |
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