Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents

Human enterovirus (EV) belongs to the picornavirus family, which consists of over 200 medically relevant viruses. A peptidomimetic inhibitor AG7088 was developed to inhibit the 3C protease of rhinovirus (a member of the family), a chymotrypsin-like protease required for viral replication, by forming...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Kuo, Chih-Jung, Shie, Jiun-Jie, Fang, Jim-Min, Yen, Guei-Rung, Hsu, John T.-A., Liu, Hun-Ge, Tseng, Sung-Nain, Chang, Shih-Cheng, Lee, Ching-Yin, Shih, Shin-Ru, Liang, Po-Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125518/
https://ncbi.nlm.nih.gov/pubmed/18583140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.06.015
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