Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity

Gentamicin is a nephrotoxic antibiotic that causes acute kidney injury (AKI) primarily by targeting the proximal tubule epithelial cell. The development of an effective therapy for gentamicin-induced renal cell injury is limited by incomplete mechanistic insight. To address this challenge, we propos...

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Pubblicato in:Cell Death Dis
Autori principali: Igwebuike, Chinaemere, Yaglom, Julia, Huiting, Leah, Feng, Hui, Campbell, Joshua D., Wang, Zhiyong, Havasi, Andrea, Pimentel, David, Sherman, Michael Y., Borkan, Steven C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125232/
https://ncbi.nlm.nih.gov/pubmed/32245975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2382-7
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