Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used quantitative proteomics in a mouse neuronal-like cell line (Neuro2a) to demonstrate that the Arg residues in the most toxic DPRS, PR and GR, leads to a promiscuous binding...

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Publicat a:Mol Cell Proteomics
Autors principals: Radwan, Mona, Ang, Ching-Seng, Ormsby, Angelique R., Cox, Dezerae, Daly, James C., Reid, Gavin E., Hatters, Danny M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124463/
https://ncbi.nlm.nih.gov/pubmed/32086375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001888
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