Activin type II receptor signaling in cardiac aging and heart failure

Activin type II receptor (ActRII) ligands have been implicated in muscle wasting in aging and disease. However, the role of these ligands and ActRII signaling in the heart remains unclear. Here, we investigated this catabolic pathway in human aging and heart failure (HF) using circulating follistati...

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Published in:Sci Transl Med
Main Authors: Roh, Jason D., Hobson, Ryan, Chaudhari, Vinita, Quintero, Pablo, Yeri, Ashish, Benson, Mark, Xiao, Chunyang, Zlotoff, Daniel, Bezzerides, Vassilios, Houstis, Nicholas, Platt, Colin, Damilano, Federico, Lindman, Brian R., Elmariah, Sammy, Biersmith, Michael, Lee, Se-Jin, Seidman, Christine E., Seidman, Jonathan G., Gerszten, Robert E., Lach-Trifilieff, Estelle, Glass, David J., Rosenzweig, Anthony
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124007/
https://ncbi.nlm.nih.gov/pubmed/30842316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau8680
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