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Manipulation of the Coronavirus Genome Using Targeted RNA Recombination with Interspecies Chimeric Coronaviruses

Targeted RNA recombination has proven to be a powerful tool for the genetic engineering of the coronavirus genome, particularly in its 3′ part. Here we describe procedures for the generation of recombinant and mutant mouse hepatitis virus and feline infectious peritonitis virus. Key to the two-step...

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Detalhes bibliográficos
Publicado no:SARS- and Other Coronaviruses
Main Authors: de Haan, Cornelis A.M., Haijema, Bert Jan, Masters, Paul S., Rottier, Peter J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7120397/
https://ncbi.nlm.nih.gov/pubmed/19057874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-59745-181-9_17
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