IFN-γ and CD25 drive distinct pathological features during hemophagocytic lymphohistiocytosis

BACKGROUND: The inflammatory activation of CD8(+) T cells can, when unchecked, drive severe immunopathology. Hyper-stimulation of CD8(+) T cells, through a broad set of triggering signals, can precipitate hemophagocytic lymphohistiocytosis (HLH), a life-threatening systemic inflammatory disorder. OB...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Humblet-Baron, Stéphanie, Franckaert, Dean, Dooley, James, Ailal, Fatima, Bousfiha, Aziz, Deswarte, Caroline, Oleaga-Quintas, Carmen, Casanova, Jean-Laurent, Bustamante, Jacinta, Liston, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117880/
https://ncbi.nlm.nih.gov/pubmed/30578871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.10.068
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