Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of obese female mice

Regulatory T cells (Treg) play essential roles in maintaining immune homeostasis. Resident Treg in visceral adipose tissue (VAT-Treg) decrease in male obese mice, which leads to the development of obesity-associated chronic inflammations and insulin resistance. Although gender differences in immune...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ishikawa, Akari, Wada, Tsutomu, Nishimura, Sanshiro, Ito, Tetsuo, Okekawa, Akira, Onogi, Yasuhiro, Watanabe, Eri, Sameshima, Azusa, Tanaka, Tomoko, Tsuneki, Hiroshi, Saito, Shigeru, Sasaoka, Toshiyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117686/
https://ncbi.nlm.nih.gov/pubmed/32240221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230885
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