Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

The repair of inflamed, demyelinated lesions as in multiple sclerosis necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subsequently, oligodendrocytes increase cholesterol levels as...

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Publicado no:Nat Neurosci
Main Authors: Berghoff, Stefan A., Spieth, Lena, Sun, Ting, Hosang, Leon, Schlaphoff, Lennart, Depp, Constanze, Düking, Tim, Winchenbach, Jan, Neuber, Jonathan, Ewers, David, Scholz, Patricia, van der Meer, Franziska, Cantuti-Castelvetri, Ludovico, Sasmita, Andrew O., Meschkat, Martin, Ruhwedel, Torben, Möbius, Wiebke, Sankowski, Roman, Prinz, Marco, Huitinga, Inge, Sereda, Michael W., Odoardi, Francesca, Ischebeck, Till, Simons, Mikael, Stadelmann-Nessler, Christine, Edgar, Julia M., Nave, Klaus-Armin, Saher, Gesine
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116742/
https://ncbi.nlm.nih.gov/pubmed/33349711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-00757-6
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