Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naïve Pluripotency

Mbd3, a member of Nucleosome Remodeling and Deacetylase (NuRD) co-repressor complex, was previously identified as an inhibitor for deterministic iPSC reprogramming where up to 100% of donor cells successfully complete the process. NuRD can assume multiple mutually-exclusive conformations, and it rem...

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Gepubliceerd in:Cell Stem Cell
Hoofdauteurs: Mor, Nofar, Rais, Yoach, Sheban, Daoud, Peles, Shani, Aguilera-Castrejon, Alejandro, Zviran, Asaf, Elinger, Dalia, Viukov, Sergey, Geula, Shay, Krupalnik, Vladislav, Zerbib, Mirie, Chomsky, Elad, Lasman, Lior, Shani, Tom, Bayerl, Jonathan, Gafni, Ohad, Hanna, Suhair, Buenrostro, Jason D., Hagai, Tzachi, Masika, Hagit, Vainorius, Gintautas, Bergman, Yehudit, Greenleaf, William J., Esteban, Miguel A., Elling, Ulrich, Levin, Yishai, Massarwa, Rada, Merbl, Yifat, Novershtern, Noa, Hanna, Jacob H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116536/
https://ncbi.nlm.nih.gov/pubmed/30122475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.07.004
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