Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

The epigenetic dynamics of iPSC reprogramming in correctly reprogrammed cells at high resolution and throughout the entire process, remain largely undefined. Here we characterize conversion of mouse fibroblasts into iPSCs using Gatad2a-Mbd3/NuRD depleted and highly efficient reprogramming systems. U...

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Publicado no:Cell Stem Cell
Main Authors: Zviran, Asaf, Mor, Nofar, Rais, Yoach, Gingold, Hila, Peles, Shani, Chomsky, Elad, Viukov, Sergey, Buenrostro, Jason D., Scognamiglio, Roberta, Weinberger, Leehee, Manor, Yair S., Krupalnik, Vladislav, Zerbib, Mirie, Hezroni, Hadas, Jaitin, Diego Adhemar, Larastiaso, David, Gilad, Shlomit, Benjamin, Sima, Gafni, Ohad, Mousa, Awni, Ayyash, Muneef, Sheban, Daoud, Bayerl, Jonathan, Castrejon, Alejandro Aguilera, Massarwa, Rada, Maza, Itay, Hanna, Suhair, Stelzer, Yonatan, Ulitsky, Igor, Greenleaf, William J., Tanay, Amos, Trumpp, Andreas, Amit, Ido, Pilpel, Yitzhak, Novershtern, Noa, Hanna, Jacob H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116520/
https://ncbi.nlm.nih.gov/pubmed/30554962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.11.014
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