Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude(1). Heavily glycosylated S trimers bind the ACE2 receptor and mediate entry of virions into target cells(2–6). S exhibits extensive conformational flex...

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Pubblicato in:Nature
Autori principali: Ke, Zunlong, Oton, Joaquin, Qu, Kun, Cortese, Mirko, Zila, Vojtech, McKeane, Lesley, Nakane, Takanori, Zivanov, Jasenko, Neufeldt, Christopher J., Cerikan, Berati, Lu, John M., Peukes, Julia, Xiong, Xiaoli, Kräusslich, Hans-Georg, Scheres, Sjors H.W., Bartenschlager, Ralf, Briggs, John A.G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116492/
https://ncbi.nlm.nih.gov/pubmed/32805734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2665-2
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