Hypoxia-induced TGF-β–RBFOX2–ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer

Hypoxic microenvironment heralds epithelial–mesenchymal transition (EMT), invasion and metastasis in solid tumors. Deregulation of alternative splicing (AS) of several cancer-associated genes has been instrumental in hypoxia-induced EMT. Our study in breast cancer unveils a previously unreported mec...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:NAR Cancer
Autori principali: Ahuja, Neha, Ashok, Cheemala, Natua, Subhashis, Pant, Deepak, Cherian, Anna, Pandkar, Madhura R, Yadav, Pooja, Narayanan S.S., Vishnu, Mishra, Jharna, Samaiya, Atul, Shukla, Sanjeev
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Cancer-specific RNAs and RNA Processing
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116222/
https://ncbi.nlm.nih.gov/pubmed/33089214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa021
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