CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

The post-genomic era has seen many advances in our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic screening with chemical genetics to identify pre-mRNA endonuclease Cleavage and Pol...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., Beckwith, Rohan E.J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116157/
https://ncbi.nlm.nih.gov/pubmed/31819276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0424-1
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