Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

We have identified a series of 1-aryl-4,6-diamino-1,2-dihydrotriazines, structurally related to the antimalarial drug cycloguanil, as new inhibitors of influenza A and B virus and respiratory syncytial virus (RSV) via targeting of the host dihydrofolate reductase (DHFR) enzyme. Most analogues proved...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Tonelli, Michele, Naesens, Lieve, Gazzarrini, Sabrina, Santucci, Matteo, Cichero, Elena, Tasso, Bruno, Moroni, Anna, Costi, Maria Paola, Loddo, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115580/
https://ncbi.nlm.nih.gov/pubmed/28477572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.04.070
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