Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation

A number of 5-arylisatin derivatives were synthesized in 5–6 steps from readily available starting materials. Their structures were confirmed by (1)H NMR and (13)C NMR as well as LC/MS. The cytotoxicity of these novel isatins against human leukemia K562 cells were evaluated by MTT assay in vitro. SA...

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Bibliographische Detailangaben
Veröffentlicht in:Eur J Med Chem
Hauptverfasser: Zhang, Qian, Teng, Yuou, Yuan, Yuan, Ruan, Tingting, Wang, Qi, Gao, Xing, Zhou, Yao, Han, Kailin, Yu, Peng, Lu, Kui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Masson SAS. 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115506/
https://ncbi.nlm.nih.gov/pubmed/30055465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.07.032
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