Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: Revealing the critical antigenic determinants in inactivated SARS-CoV vaccine

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is considered as a major antigen for vaccine design. We previously demonstrated that the receptor-binding domain (RBD: residues 318–510) of S protein contains multiple conformation-dependent neutralizing epitopes (Conf...

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Udgivet i:Vaccine
Main Authors: He, Yuxian, Li, Jingjing, Du, Lanying, Yan, Xuxia, Hu, Guangan, Zhou, Yusen, Jiang, Shibo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Ltd. 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115380/
https://ncbi.nlm.nih.gov/pubmed/16725238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2006.04.054
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