A Strategic Target Rescues Trimethoprim Sensitivity in Escherichia coli

Trimethoprim, a preferred treatment for urinary tract infections, is becoming obsolete owing to the rapid dissemination of resistant E. coli. Although direct resistance mechanisms such as overexpression of a mutant FolA and dfr enzymes are well characterized, associated alterations that drive or sus...

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Veröffentlicht in:iScience
Hauptverfasser: Bhosle, Amrisha, Datey, Akshay, Chandrasekharan, Giridhar, Singh, Deepshikha, Chakravortty, Dipshikha, Chandra, Nagasuma
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115098/
https://ncbi.nlm.nih.gov/pubmed/32240953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100986
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