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Sequencing Shorter cfDNA Fragments Decreases the False Negative Rate of Non-invasive Prenatal Testing

Circulating fetal cell-free DNA (cfDNA) is generally shorter than maternal cfDNA. Size selection of shorter cfDNA in total cfDNA could significantly increase the fetal fraction, but there are few reports of using this method to decrease the false negative rate for NIPT. In this study, nine false neg...

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Dettagli Bibliografici
Pubblicato in:Front Genet
Autori principali: Xue, Ying, Zhao, Guodong, Qiao, Longwei, Lu, Jiafeng, Yu, Bin, Wang, Ting
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114958/
https://ncbi.nlm.nih.gov/pubmed/32273885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00280
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