Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus

To study the roles of hypervariable regions (HVRs) in receptor-binding subunit S1 of the spike protein, we manipulated the genome of the IBV Beaudette strain using a reverse genetics system to construct seven recombinant strains by separately or simultaneously replacing the three HVRs of the Beaudet...

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Vydáno v:Virus Res
Hlavní autoři: Shan, Dan, Fang, Shouguo, Han, Zongxi, Ai, Hui, Zhao, Wenjun, Chen, Yuqiu, Jiang, Lei, Liu, Shengwang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier B.V. 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114591/
https://ncbi.nlm.nih.gov/pubmed/29684409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2018.04.013
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