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Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As s...

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書誌詳細
出版年:Virus Res
主要な著者: Carbajo-Lozoya, Javier, Müller, Marcel A., Kallies, Stephan, Thiel, Volker, Drosten, Christian, von Brunn, Albrecht
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier B.V. 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114512/
https://ncbi.nlm.nih.gov/pubmed/22349148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.02.002
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