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Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As s...

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Foilsithe in:Virus Res
Main Authors: Carbajo-Lozoya, Javier, Müller, Marcel A., Kallies, Stephan, Thiel, Volker, Drosten, Christian, von Brunn, Albrecht
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier B.V. 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114512/
https://ncbi.nlm.nih.gov/pubmed/22349148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.02.002
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