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Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As s...

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Dettagli Bibliografici
Pubblicato in:Virus Res
Autori principali: Carbajo-Lozoya, Javier, Müller, Marcel A., Kallies, Stephan, Thiel, Volker, Drosten, Christian, von Brunn, Albrecht
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier B.V. 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114512/
https://ncbi.nlm.nih.gov/pubmed/22349148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.02.002
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