Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As s...

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Detalhes bibliográficos
Publicado no:Virus Res
Main Authors: Carbajo-Lozoya, Javier, Müller, Marcel A., Kallies, Stephan, Thiel, Volker, Drosten, Christian, von Brunn, Albrecht
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114512/
https://ncbi.nlm.nih.gov/pubmed/22349148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.02.002
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