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Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
SARS coronavirus main protease (SARS-CoV M(pro)) is essential for the replication of the virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with a catalytic dyad (Cys-145/His-41) in the active site. Aldehyde inhibitors can bind reversibly to the active-site sulfh...
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| Publicado no: | Antiviral Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier B.V.
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7114241/ https://ncbi.nlm.nih.gov/pubmed/21854807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.08.001 |
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