The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

Zika virus (ZIKV) is a human-pathogenic flavivirus that has recently emerged as a global public health threat. ZIKV infection may be associated with congenital malformations in infected fetuses and severe neurological and systemic complications in infected adults. There are currently limited treatme...

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Bibliographische Detailangaben
Veröffentlicht in:Antiviral Res
Hauptverfasser: Chan, Jasper Fuk-Woo, Zhu, Zheng, Chu, Hin, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yip, Cyril Chik-Yan, Zhang, Xi, Tsang, Jessica Oi-Ling, Zou, Zijiao, Tee, Kah-Meng, Shuai, Huiping, Lu, Gang, Yuen, Kwok-Yung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier B.V. 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113887/
https://ncbi.nlm.nih.gov/pubmed/30326204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2018.10.007
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