Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

The Middle-East Respiratory Syndrome coronavirus (MERS-CoV) causes severe acute pneumonia and renal failure. The MERS-CoV papain-like protease (PL(pro)) is a potential target for the development of antiviral drugs. To facilitate these efforts, we determined the three-dimensional structure of the enz...

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Veröffentlicht in:Antiviral Res
Hauptverfasser: Lei, Jian, Mesters, Jeroen R., Drosten, Christian, Anemüller, Stefan, Ma, Qingjun, Hilgenfeld, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Authors. Published by Elsevier B.V. 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113875/
https://ncbi.nlm.nih.gov/pubmed/24992731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.06.011
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