Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes

Over 18 million disease cases and half a million deaths worldwide are estimated to be caused annually by Group A Streptococcus. A vaccine to prevent GAS disease is urgently needed. SpyCEP (Streptococcus pyogenes Cell-Envelope Proteinase) is a surface-exposed serine protease that inactivates chemokin...

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Publicado en:Comput Struct Biotechnol J
Main Authors: McKenna, Sophie, Malito, Enrico, Rouse, Sarah L., Abate, Francesca, Bensi, Giuliano, Chiarot, Emiliano, Micoli, Francesca, Mancini, Francesca, Gomes Moriel, Danilo, Grandi, Guido, Mossakowska, Danuta, Pearson, Max, Xu, Yingqi, Pease, James, Sriskandan, Shiranee, Margarit, Immaculada, Bottomley, Matthew J., Matthews, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113628/
https://ncbi.nlm.nih.gov/pubmed/32257048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.03.004
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