Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

BACKGROUND: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are highly up‐regulat...

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Detalhes bibliográficos
Publicado no:J Cachexia Sarcopenia Muscle
Main Authors: van Westering, Tirsa L.E., Lomonosova, Yulia, Coenen‐Stass, Anna M.L., Betts, Corinne A., Bhomra, Amarjit, Hulsker, Margriet, Clark, Lucy E., McClorey, Graham, Aartsma‐Rus, Annemieke, van Putten, Maaike, Wood, Matthew J.A., Roberts, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113513/
https://ncbi.nlm.nih.gov/pubmed/31849191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12506
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