IL-17 Inhibition in Spondyloarthritis Associates with Subclinical Gut Microbiome Perturbations and a Distinctive IL-25-Driven Intestinal Inflammation

OBJECTIVE: To characterize the ecological effects of biologic therapies on the gut bacterial and fungal microbiome of psoriatic arthritis (PsA)/spondyloarthritis (SpA) patients. METHODS: Fecal samples from PsA/SpA patients pre- and post-treatment with tumor necrosis factor inhibitors (TNFi; n=15) or...

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書誌詳細
出版年:Arthritis Rheumatol
主要な著者: Manasson, Julia, Wallach, David S., Guggino, Giuliana, Stapylton, Matthew, Badri, Michelle H., Solomon, Gary, Reddy, Soumya M., Coras, Roxana, Aksenov, Alexander A., Jones, Drew R., Girija, Parvathy V., Neimann, Andrea L., Heguy, Adriana, Segal, Leopoldo N., Dorrestein, Pieter C., Bonneau, Richard, Guma, Monica, Ciccia, Francesco, Ubeda, Carles, Clemente, Jose C., Scher, Jose U.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113119/
https://ncbi.nlm.nih.gov/pubmed/31729183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41169
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