IL-17 Inhibition in Spondyloarthritis Associates with Subclinical Gut Microbiome Perturbations and a Distinctive IL-25-Driven Intestinal Inflammation

OBJECTIVE: To characterize the ecological effects of biologic therapies on the gut bacterial and fungal microbiome of psoriatic arthritis (PsA)/spondyloarthritis (SpA) patients. METHODS: Fecal samples from PsA/SpA patients pre- and post-treatment with tumor necrosis factor inhibitors (TNFi; n=15) or...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Manasson, Julia, Wallach, David S., Guggino, Giuliana, Stapylton, Matthew, Badri, Michelle H., Solomon, Gary, Reddy, Soumya M., Coras, Roxana, Aksenov, Alexander A., Jones, Drew R., Girija, Parvathy V., Neimann, Andrea L., Heguy, Adriana, Segal, Leopoldo N., Dorrestein, Pieter C., Bonneau, Richard, Guma, Monica, Ciccia, Francesco, Ubeda, Carles, Clemente, Jose C., Scher, Jose U.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113119/
https://ncbi.nlm.nih.gov/pubmed/31729183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41169
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