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LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation, chromosomal segregation, and nuclear migration. Recen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Moon, Hyang Mi, Hippenmeyer, Simon, Luo, Liqun, Wynshaw-Boris, Anthony
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112955/
https://ncbi.nlm.nih.gov/pubmed/32159512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51512
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