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WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility

Cell motility is governed by cooperation between the Arp2/3 complex and nucleation-promoting factors from the Wiskott-Aldrich Syndrome Protein (WASP) family, which together assemble actin filament networks to drive membrane protrusion. Here we identify WHIMP (WAVE Homology In Membrane Protrusions) a...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Kabrawala, Shail, Zimmer, Margaret D., Campellone, Kenneth G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112243/
https://ncbi.nlm.nih.gov/pubmed/32196488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008694
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