TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway

BACKGROUND: TBX5 is a transcription factor that has an important role in development of heart. TBX5 variants in the region encoding the T-box domain have been shown to cause cardiac defects, such as atrial septal defect or ventricular septal defect, while TBX5 variants have also been identified in a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Miyao, Nariaki, Hata, Yukiko, Izumi, Hironori, Nagaoka, Ryo, Oku, Yuko, Takasaki, Ichiro, Ishikawa, Taisuke, Takarada, Shinya, Okabe, Mako, Nakaoka, Hideyuki, Ibuki, Keijiro, Ozawa, Sayaka, Yoshida, Tomoyuki, Hasegawa, Hideyuki, Makita, Naomasa, Nishida, Naoki, Mori, Hisashi, Ichida, Fukiko, Hirono, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112173/
https://ncbi.nlm.nih.gov/pubmed/32236096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227393
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